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JOHN F PATZER II, Ph.D.
Associate Professor, Department of Bioengineering
Associate Professor, Department of Chemical Engineering
Associate Professor, Department of Surgery
| Email: |
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| Phone: |
(412) 624-9819 |
| Fax: |
(412) 383-8788 |
| Office: |
309 CNBIO |
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Education
B.S., Chemical Engineering, Michigan State University, 1971
M.S., Chemical Engineering, Michigan State University, 1973
Ph.D., Chemical Engineering (Fluid Mechanics), Stanford University, 1980
Professional Interests
Dr. Patzer's research involves the application of reaction engineering, transport phenomena, electrochemistry, and metabolic catalysis to biomedical approaches to internal organ regeneration and function replacement. His primary research interests are in the development (laboratory, preclinical, and clinical) of metabolic artificial organs, primarily liver, kidney, and pancreas.
Following several years of industrial experience with Gulf Research & Development Company, Dr Patzer joined the Department of Chemical Engineering at the University of Pittsburgh where he collaborated in development of a portable artificial kidney and implantable glucose sensors. He then transferred to the Department of Surgery after establishing a basic research, preclinical, and clinical program in bioartificial liver assist devices that encompasses researchers and clinicians from several departments collaborating to bring novel approaches for treatment of liver failure to clinical evaluation. Of particular note is an extramural collaboration on design and development of a bioartificial liver based upon porcine hepatocytes that Dr Patzer guided from concept through large animal preclinical evaluation and into clinical Phase I evaluation in less than three years (with FDA and IRB approval).
Most recently, Dr Patzer has joined the Department of Bioengineering where he continues to work in the area of liver support with projects on the use of binding agents to promote removal of liver toxins in acute liver failure; mitigation of transplant associated reperfusion injury; metabolic liver support in split liver transplantation; and inference of intracranial pressure elevation from transcranial doppler ultrasound. He is also collaborating with investigators from the McGowan Institute to develop novel cell-based approaches to skin regeneration.
Selected Publications
- Patzer II JF, Lopez RC, Zhu Y, Wang Z-F, Mazariegos GV, Fung JJ: Bioartificial liver assist devices in support of patients with liver failure. Hepatobiliary & Pancreatic Diseases International 2002; 1:18-25
- Kuddus R, Patzer II JF, Lopez R, Mazariegos GV, Meighen B, Kramer DJ, Rao AS: Clinical and laboratory evaluation of the safety of a bioartificial liver assist device for potential transmission of porcine endogenous retrovirus. Transplantation 2002; 73:420-429.
- Mazariegos GV, Patzer II JF, Lopez RC, Giraldo M, DeVera MD, Grogan TA, Zhu Y, Fulmer ML, Amiot BP, Kramer DJ: First clinical use of a novel bioartificial liver support system (BLSS). American Journal of Transplantation 2002; 2:260-266.
- Patzer II JF, Campbell B, Miller R: Plasma versus whole blood perfusion in a bioartificial liver assist device. ASAIO Journal 2002; 48:226-233.
- Patzer II JF, Mazariegos GV, Lopez R, Bioartificial Liver Program Investigators: Preclinical evaluation of the Excorp Medical, Inc. bioartificial liver support system (BLSS). Journal of the American College of Surgeons 2002; 195:299-310.
- Patzer II JF, Block GD, Khanna A, Yin W-Y, Molmenti E, Gerber D, Kramer DJ, Scott VL, Aggarwal S, Wagner RA, Fulmer ML, Amiot BP, Mazariegos GV: D-galactosamine based canine acute liver failure model. Hepatobiliary & Pancreatic Diseases International 2002; 1:354-367.
- Patzer II JF, Bane SE: Bound solute dialysis. ASAIO J 2003; 49:271-281.
- Patzer II JF: Oxygen consumption in a hollow fiber bioartificial liver - revisited. Artificial Organs 2004; 28:83-98.
- Patzer II JF, Safta SA, Miller RH: Slow continuous ultrafiltration with bound solute dialysis. ASAIO J 2006;52:47-58.
- Patzer II JF: Principles of bound solute dialysis. Therapeutic Apheresis and Dialysis 2006;10:118-124.
- Patzer II JF, Lopez RC, Aggarwal, S: Intracranial pressure observations in a canine model of acute liver failure supported by a bioartificial liver support system. Artificial Organs 2007;11:834-839.
- Patzer II JF: Thermodynamic considerations in solid adsorption of bound solutes for patient support in liver failure. Accepted - Artificial Organs 2008.
- Aggarwal S, Brooks DM, Kang Y, Linden PK, Patzer II JF: Non-invasive monitoring of cerebral perfusion pressure in patients with acute liver failure using transcranial doppler ultrasonography. Accepted - Liver Transplantation 2008.
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