Undergraduate Courses BIOENG 1810

BIOENG 1810 - Biomaterials and Biocompatibility

Instructor: Cui

Credits: 3

Term: Fall

Description: This course is designed to introduce undergraduate students to a more advanced understanding of biomaterials. Throughout the course ties are made between the topic of study and clinically relevant biomaterial performance. The course will introduce various biomaterials such as polymers, metals, and ceramics with the focus on their synthesis, characterization, structure-property relationship and surface modification. The biocompatibility issues of biomaterials will be discussed from different aspects such as protein adsorption, foreign body reaction, immune and inflammatory response and sterilization. Finally, examples of clinical applications will be given.

Prerequisites: CHEM 0310 and BIOSC 1000

Required Texts: Biomaterials Science: An Introduction to Materials in Medicine, edited by Ratner BD, Hoffman AS, Schoen FJ, Lemons JE, New York, Academic Press, 2004.

Course Objectives: The purpose of this introductory course is to introduce students to biomaterials and the use of biomaterials in areas such as tissue engineering, artificial organs and implantable medical devices. Upon completing this course, students should:

understand the basic principles behind human tissue response to artificial surface implantation,
be familiar with the general types of materials used in soft and hard tissue replacements, drug delivery devices, and extracorporeal devices,
understand techniques utilized to control the physiologic response to artificial surfaces,
be familiar with the design strategies and clinical applications of biomaterials

Topics Covered:

Material science of (polymer, metals, ceramics, glasses, and nature derived materials)
Surface modification and immobilization
Protein adsorption and cell adhesion
Immune response, inflammatory response and foreign body reaction
Infection and sterilization
In vitro and in vivo evaluation
Clinical applications (cardiovascular, neurological, drug delivery etc.)

Syllabus: Microsoft Word Format

Class/Laboratory Schedule: Class meets twice a week for 75 minutes each day.